PEPTIDE REGISTRY
2026 edition · 186 records · verified Sep 2 2026
ReferenceBasics, glossary, key, timeline, handling, research, and cautions
Nine reference notes. Everything the registry frames: the molecule, the rules, the 2026 timeline, the paperwork, what changed, and what to be careful about.
What a peptide actually is +

A peptide is a short chain of amino acids, the same building blocks that make up proteins, joined end to end by a single kind of chemical link called the peptide bond.

One amino acid is a monomer. Join two and you have a dipeptide. A chain of roughly two to fifty amino acids is a peptide; longer than that, and the chain folds into a protein. So a peptide is a protein fragment small enough to act like a precise instruction rather than a machine. Two amino acids link when the acid end of one bonds to the amino end of the next and a molecule of water is released. The chain has an amino end (N-terminus) and an acid end (C-terminus); the order read from N to C decides its shape and which receptors it fits.

20
Standard amino acids spell every peptide and protein
2–50
Amino acids in a typical peptide; longer chains are proteins
Minutes
How fast the body clears many unmodified signaling peptides
1963
Year solid-phase synthesis made building peptides routine

The body's own messaging

Most peptides here are messages, not structure. The body already runs on them: insulin, glucagon, oxytocin, and the incretin GLP-1 are all peptides. Each reaches a matching receptor and triggers a response. A peptide's small size lets it bind with high specificity while slipping through tissue more easily than a bulky protein, which is why drug makers chase them.

Why the needle

The digestive tract breaks proteins into amino acids, so a swallowed peptide is mostly dismantled before it can act, and the little that survives is filtered by the liver on first pass. A subcutaneous injection sidesteps all of that, which is why it is the default. Exceptions exist: oral semaglutide pairs the peptide with an absorption enhancer, and orforglipron sidesteps the problem by being a small molecule rather than a peptide.

Turning minutes into weeks

Signals are meant to fade, so the body clears many peptides in minutes. Attaching a fatty-acid chain lets a peptide ride along on albumin for days (how semaglutide and tirzepatide reach weekly dosing). Other tricks: PEGylation, mirror-image D-amino acids enzymes cannot grip, and cyclizing the chain into a closed loop.

Built, not grown

Peptides are assembled by solid-phase synthesis (anchor the first amino acid to a resin bead, then add the rest one at a time) or produced in engineered cells. The finished product is never perfectly clean: truncated chains, wrong residues, leftover solvents, and endotoxin can all ride along, which is why the certificate of analysis matters as much as the label.

Medicine versus research chemical. The most important distinction in this field is legal, not chemical. An approved peptide medicine has cleared human trials and is made under pharmaceutical controls. A research peptide is the same kind of molecule sold under a "laboratory use only" banner: no trials for that product, no manufacturing oversight, and no guarantee the vial holds what the sticker claims.
Glossary & acronyms +

The shorthand this guide leans on, in one place.

Regulators & rules

PCAC
Pharmacy Compounding Advisory Committee. The FDA advisory panel (docket FDA-2025-N-6895) that voted in July 2026 on whether restricted peptides such as BPC-157 and Semax may return to pharmacy compounding. Its vote is advice, not a rule.
WADA
World Anti-Doping Agency. Publishes the annual Prohibited List that decides what athletes may not use, in and out of competition.
TUE
Therapeutic Use Exemption. The WADA process that lets a specific athlete use an otherwise-banned substance (for example, insulin) for a documented medical need.
Category 2
FDA's list of bulk drug substances with safety concerns that generally may not be compounded. A peptide moving off Category 2 reopens legal pharmacy compounding.
503A / 503B
The two FDA compounding categories: 503A traditional compounding pharmacies and 503B outsourcing facilities.
Vote notation
A PCAC tally such as "8–6–1" reads yes–no–abstain.

WADA Prohibited List sections

S0
Non-approved substances: anything with no regulatory approval for human therapeutic use.
S2
Peptide hormones, growth factors, related substances and mimetics (hGH, GHRH, GHRPs, IGF-1, TB-500, and similar).
S4.3
Myostatin inhibitors and activin receptor IIB antagonists (Follistatin, ACE-031).
S4.4
Metabolic modulators.
S4.4.1
AMPK and PPAR-delta activators (AICAR, GW-501516, MOTS-c).
S4.4.2
Insulin and insulin-mimetics.

Chemistry & dosing

SubQ
Subcutaneous; an injection into the fat layer beneath the skin, the default route in this guide.
IM / IV
Intramuscular / intravenous injection.
Half-life
The time it takes for blood concentration to fall by half; the main driver of dosing frequency.
Lyophilized
Freeze-dried into a powder, the stable long-term form of a peptide.
Reconstitution
Dissolving lyophilized powder into a diluent, usually bacteriostatic water.
Bacteriostatic water (BAC)
Sterile water with 0.9% benzyl alcohol, used for multi-dose vials.
U-100 syringe
An insulin syringe where 100 units equal 1 mL, so 1 unit is 0.01 mL.
D-amino acid
The mirror-image form of an amino acid; enzymes cannot grip it, so it extends a peptide's life.

Quality & lab

COA
Certificate of Analysis; a batch's lab report.
HPLC
High-performance liquid chromatography; the purity test (what fraction is the target peptide).
LC-MS
Liquid chromatography-mass spectrometry; the identity test (confirms the molecule).
Endotoxin
Fragments of bacterial cell walls; can cause fever and shock if injected.

Common abbreviations

GLP-1
Glucagon-like peptide-1; the incretin receptor behind semaglutide and tirzepatide.
GHRH
Growth hormone-releasing hormone.
GHRP
Growth hormone-releasing peptide (GHRP-2, GHRP-6).
IGF-1
Insulin-like growth factor 1; the growth factor downstream of growth hormone.
hGH
Human growth hormone.
TB-4 / TB-500
Thymosin Beta-4 and its synthetic TB-500 fragment.
BPC-157
"Body Protection Compound 157," a 15-amino-acid peptide.
Function key +

Every record carries a second, functional color on its left and top edge and its chip, alongside its class numeral. This groups compounds by what they actually do, cutting across the seven categories.

Function colors by class

Which functions appear inside each of the seven classes, with record counts. A class can span several functions, and a function can span several classes.

Dosing protocols & reconstitution +

Records with a matching page on PeptideDosingProtocols.com carry a SubQ dosing reference with U-100 syringe conversions for 2 mL and 3 mL bacteriostatic water. This note covers the technique that sits behind every one of those tables.

Clinical trial User research No human data Every protocol in this guide is tagged with where its dose comes from. Clinical trial: a regulatory label (FDA, EMA, China, Japan, Russia) or a published, registered human trial. User research: community consensus averaged from Reddit and biohacking boards plus vendor reference sites, not a formal trial. No human data: the compound is preclinical or a lab reagent with no established human dose, shown for reference only. A record can carry more than one tag, for example both Clinical trial and User research, when a formal trial dose and a community consensus both exist.

Reconstituting a lyophilized vial

  1. Check the label: confirm the milligram content and that the powder looks dry and intact.
  2. Swab both rubber stoppers (the peptide vial and the BAC-water vial) with alcohol.
  3. Draw the water. The tables in this guide use 2 mL or 3 mL, usually across two draws.
  4. Inject slowly down the inside wall of the vial, not directly onto the powder.
  5. Swirl gently (roll between your palms). Never shake; it can damage the peptide.
  6. Verify the solution is clear and colorless. Cloudiness or particles mean discard.
  7. Refrigerate (2–8 °C), and label the vial with the date and concentration.

Injecting subcutaneously

  1. Sites: abdomen (about 2 in from the navel), outer thigh, or back of the upper arm. Rotate every dose.
  2. Use a fresh U-100 syringe and swab per dose; let the alcohol fully dry.
  3. Pinch a fold of skin and inject at 45° (or 90° where there is more tissue).
  4. Inject slowly. A slow push markedly reduces stinging with NAD+, VIP, and similar compounds.

Storage rules

Lyophilized powder is the stable form: frozen (-20 °C), dry, and dark for long-term holding. Reconstituted solution is fragile: refrigerate (2–8 °C) and use within roughly 2–4 weeks (28 days is the common default), never freeze it. Multi-dose vials need bacteriostatic water (0.9% benzyl alcohol), not plain sterile water or saline.

The unit math, once

On a U-100 syringe, 100 units = 1 mL, so 1 unit = 0.01 mL. concentration = vial mg ÷ water mL, and units = dose ÷ (concentration × 0.01). A 10 mg vial in 2 mL is 5 mg/mL, so a 250 mcg (0.25 mg) dose is 5 units; the same vial in 3 mL is 3.33 mg/mL, so 250 mcg becomes 7.5 units.

These are research-planning references, not prescriptions. Where a compound's documented route is not subcutaneous (oral tesofensine, IM/IV cerebrolysin and glutathione), the entry says so instead of inventing a SubQ protocol. For approved drugs the FDA label governs, and the community figures shown never override it.

The 2026 regulatory timeline +
  • Feb 27HHS opens the door. Secretary RFK Jr. signals intent to move roughly 14 of 19 restricted peptides back toward legal compounding.
  • Apr 2312 peptides come off Category 2. BPC-157, TB-500, KPV, MOTS-c, Semax, Epitalon, DSIP, Melanotan II, LL-37, PEG-MGF, Dihexa, and injectable GHK-Cu. Not drug approval; only a reopening of possible pharmacy compounding. GHRP-2 and GHRP-6 stay restricted. Five of the twelve are deferred to a second review expected before February 2027.
  • Jun 29The jury changes. FDA names eight new PCAC panelists, at least seven with financial or clinical ties to peptide clinics.
  • Jul 1FDA scientists push back. Staff briefing documents: insufficient evidence and unresolved safety concerns for all seven peptides under review.
  • Jul 23–24The hearing. PCAC reviews BPC-157, KPV, TB-500, and MOTS-c on the 23rd; Semax, Epitalon, and DSIP on the 24th.
  • Jul 24Six favorable recommendations, one unfavorable. BPC-157, KPV, TB-500 (8–6–1 each), MOTS-c (7–5–2), Epitalon (7–4–1), Semax (8–5–1). Emideltide (DSIP) was unfavorable at 6–7–1. Advisory only; rulemaking, typically 8 to 24 months, still follows.
  • Apr–JulGLP-1 compounding closes. FDA proposes to exclude semaglutide, tirzepatide, and liraglutide from the 503B bulks list. Comment window extended to July 30, 2026; final rule pending.
  • Jul 30The comment window shuts. Thousands of formal comments logged; no final rule yet. The same week brought the first major criminal sentence in the research-peptide market: the owner of Paradigm Peptides drew 70 months in federal prison for selling unapproved drugs with forged certificates of analysis, some adulterated with testosterone (DOJ, Jul 31).
  • Aug 5Orexin replacement approved. FDA clears Orzeyful (oveporexton), the first drug for narcolepsy type 1 as a complete disorder and the first medicine to act directly on the orexin system; oral tablet, twice daily, Breakthrough Therapy + Priority Review.
  • Aug 12Lilly sues six sellers of unapproved retatrutide. Lawsuits name Striker Pharmacy, Aesthetic Envy, Astra Peptides, Legendary Peptides, Texas Peptides, and Lone Star Peptide over "research use only" vials of the not-yet-approved triple agonist. Lilly says it has referred more than 200 people and entities to regulators and flagged more than 14,000 websites and listings across 100+ countries.
  • Aug 14–18Peptide-panel conflicts questioned. A consumer watchdog urges HHS to investigate financial conflicts among the PCAC members who backed the six peptides, alleging "disqualifying financial interests"; FDA and HHS have not yet responded, and the watchdog escalated with a formal conflict-of-interest request to the HHS Inspector General in late August.
  • Aug 19An FDA commissioner nominee is announced. President Trump nominates Dr. Heidi Overton as FDA commissioner, filling the vacancy left by Dr. Marty Makary; Senate confirmation remains pending and separate from any pending compounding rulemaking.
  • Aug 24–26The gray-market retatrutide study gets its numbers. A preprint from health-data firm nference (378 buyers, peer review ongoing) found gray-market users lost 4.7%, 5.3%, and 7.2% at 3, 6, and 12 months versus 5.7%, 11.9%, and 15.5% in trials - roughly half the benefit - while keeping the drug's characteristic heart-rate rise (+4.3 bpm at 3 months in both cohorts). Sourcing: 57% online or telehealth vendors, 29% compounding pharmacies, 9% clinics (Axios, MedPage Today, Medscape).
  • Aug 28A hepcidin mimetic becomes a medicine. FDA approves Mimrylo (rusfertide) for erythrocytosis in polycythemia vera - the first hepcidin-mimetic peptide ever approved and the second peptide-class approval of August, after Orzeyful. Weekly SubQ self-injection; in VERIFY, 76.9% of patients stayed phlebotomy-free versus 32.9% on placebo.
  • Sep 2Status check: one new peptide approval, no new compounding rules. The PCAC votes remain advisory, the proposed 503B bulk-substances exclusion remains a proposal after the July 30 comment deadline, and FDA has confirmed a second PCAC meeting before the end of February 2027 to review LL-37, GHK-Cu, Dihexa acetate, Melanotan II, and PEG-MGF.
Labels, storage & the certificate +

Reading "SKU" codes. Single-compound vials are usually [abbreviation][number], where the number is the milligram content: BPC10 is sold as 10 mg of BPC-157. That is total peptide in the vial, not a concentration. Blends drop the chemistry for a catchier name (GLOW50, KLOW80). Vendor letters carry no standard meaning.

Storage. Powder is the stable form: lyophilized, kept cold and dark, an unopened vial can last months to years, best frozen once. Reconstituted means fragile: refrigerate and use within a short window (commonly a few weeks). Cloudiness, particles, or color shift mean discard.

CERTIFICATE OF ANALYSIS
Sample BPC-157Declared 5 mg / vialBatch BPC-2604AAnalysis 2026-05-13
AppearanceWhite powderConforms
Identity (LC-MS)[M+H]+ 1420.6Conforms
Purity (HPLC)98.7%≥95%
Net peptide5.08 mgLabel 5 mg
Sterility / endotoxinNot includedNot requested

What a certificate does and does not tell you. Identity and purity are two different tests (mass spec confirms the molecule; HPLC measures how much is that molecule). >99% purity is the peptide fraction only and says nothing about sequence, fill weight, or sterility. Check who signed it and that the lot number matches the vial. A third-party lab beats an in-house sheet. Sterility and endotoxin are usually missing, and they matter most for anything injected.

Research ledger +
  • Jul 23Retatrutide TRIUMPH-2 and TRIUMPH-3. Up to 20.8% weight loss in type 2 diabetes and 22.6% in obesity with cardiovascular disease at 80 weeks, after TRIUMPH-1's 28.3% at 80 weeks and 30.3% at 104 weeks. Q1 2027 filing guided; approval realistically 2028.
  • May–JulPemvidutide broadens. Phase 2b IMPACT showed MASH resolution and better lipids and blood pressure; a July 2026 readout cut heavy drinking days, positioning it for MASH and alcohol use disorder.
  • Q1 2026Amylin and oral pills take over. Amycretin entered Phase 3 on roughly 22% at 36 weeks; MariTide's MARITIME runs into 2027; VK2735's oral form heads to Phase 3; orforglipron opened the no-restriction oral GLP-1 pill era.
  • 2025–26The peptide drug class widens. Setmelanotide, teduglutide, ziconotide, vosoritide, and teriparatide/abaloparatide sit on the approved side, expanding the class beyond GLP-1 into bone, GI, pain, and rare disease.
  • Jul 24The PCAC split, and its limits. Six favorable recommendations and one unfavorable recommendation against staff advice; Emideltide (DSIP) was the lone unfavorable vote at 6–7–1. Advisory only; watch docket FDA-2025-N-6895.
  • JunThe peptide gray market is now a measured economy. Chainalysis analysis pegs the crypto-fueled gray-market peptide trade at a $100 million+ annual run rate (reported July 7), and Stanford's AI-identified appetite peptide BRP gets wide mainstream coverage of its Nature results (50% food-intake cut in animals, no nausea), still with no human trial registered.
  • Aug 5The orexin axis goes clinical. FDA approves Orzeyful (oveporexton) for narcolepsy type 1, the first medicine to restore orexin signaling instead of masking symptoms; the class is now a validated drug target rather than a research curiosity.
  • Aug 12–20The retatrutide gray market gets its first real-world data. Lilly confirms an expanded-access program (Aug 3) letting a narrow group of patients apply for authentic retatrutide outside trials, and a preprint of 378 gray-market buyers reports roughly half the trial weight loss with the same heart-rate elevation; Lilly's six lawsuits (Aug 12) and 14,000+ flagged listings frame unapproved reta as the enforcement front of the GLP-1 era.
  • Aug 13The oral pill era starts booking revenue. Foundayo (orforglipron) posts about $98 million in Q2 2026 U.S. sales and wins UK approval for weight loss and type 2 diabetes, the first non-U.S. clearance for the no-restriction daily GLP-1 pill.
  • Aug 19An activin-axis approval lands. FDA clears garetosmab, an activin A-targeting antibody, for fibrodysplasia ossificans progressiva; not a peptide, but it is the first FDA approval on the activin/myostatin axis this guide tracks (follistatin, ACE-031, myostatin propeptide), validating that pathway as druggable.
  • Aug 3Lilly opens a pressure valve. The company confirms an expanded-access program for retatrutide: adults with severe, treatment-resistant obesity and serious complications who have exhausted other options can apply for authentic drug outside trials, after a single 79-year-old patient's compassionate-use grant drew national attention in June. Clinicians anticipate an avalanche of requests for a narrow funnel.
  • Aug 10–19Compounded-glutathione recalls land back to back. Two Texas 503A pharmacies (Victory Medical Center, then Optimal Balance, lot distributed to 14 states) recalled injectable glutathione vials for elevated bacterial endotoxin after adverse-event reports; glutathione sits on neither bulks list, so both recalls raise the legality question alongside the sterility one.
  • Aug 17–18Australia weighs the tanning peptides. The TGA warns consumers off melanotan II nasal sprays after lab testing of bottles labeled 30 mg found roughly 22 to 54 mg of actual content, and reports a seventh Australian case of acute liver failure after black-market retatrutide injection, speculating about a bad batch. South Carolina's medical board separately told physicians the same week that research-grade peptides may not be prescribed.
  • Aug 28The peptide-drug class adds its first hepcidin mimetic. Mimrylo (rusfertide, Takeda/Protagonist) is approved for polycythemia vera: a weekly SubQ self-injection that mimics the iron-regulating hormone hepcidin, cutting phlebotomy need in more than three quarters of trial patients. Protagonist's second 2026 peptide approval after icotrokinra.
  • Sep 2Where things stand. The compounding docket, the GLP-1 503B exclusion, and the FDA commissioner nomination are all still in motion; the pipeline (CagriSema, retatrutide, survodutide) readies late-2026 filings; and enforcement plus quality failures now generate a steady drumbeat of their own news cycle.
  • OngoingThe evidence gap is the real story. Outside approved medicines, human outcome data remains thin while the grey-market catalog expands faster than the science; by mid-2026 that gap had its own news cycle, from a Nature feature on the peptide craze (June 9) and Medscape's "Gray Market Peptides: So Much Hype, So Little Data" (April 30) to Stanford's Rachele Pojednic telling the AP (August 2) that influencer claims are "really just hype" built on repetition rather than evidence.
Patterns worth noticing +

The same building blocks. BPC-157, TB-500, GHK-Cu, and KPV keep reappearing inside blends; GLOW, KLOW, and "Wolverine" are remixes with no new chemistry and no compounding status of their own.

Not all are peptides. SLU-PP-332, 5-Amino-1MQ, MK-677, and AICAR are small molecules or non-peptide mixtures sold under the same banner.

One step from a drug. PT-141 and Melanotan II share a lineage; Melanotan I shares a sequence with the approved implant Scenesse. That does not make the loose vials approved or standardized.

Community demand comes first. Forums usually form a compound's reputation months or years before a trial or PCAC nomination; regulators largely react to demand.

The biggest pattern of 2026. Regulators are loosening whether doctors can eventually prescribe compounded peptides like BPC-157 while simultaneously tightening enforcement against the unregulated retail vials selling the same molecules outside that system. Both are true at once, and a lot of marketing blurs the difference. Watch docket FDA-2025-N-6895.
The newest pattern (late August). Every thread of 2026 converged in one week: the first gray-market outcome data arrived (roughly half the trial weight loss for black-market retatrutide, with the heart-rate cost intact), the first criminal sentence landed for a research-peptide vendor (70 months, forged certificates of analysis), compounded product recalls hit two pharmacies in nine days, and a genuinely new peptide medicine (Mimrylo) reached the approved side of the ledger. The gap between the approved class and the gray market is now measured, not just argued.
A far higher-risk tier +

The same grey-market channels also move drugs that are far more dangerous. Opioid peptides like dermorphin run many times stronger than morphine. Insulin and EPO kill with some regularity when self-dosed. Human growth hormone and its fragments, and the fertility gonadotropins (hCG, HMG) are sold for self-managed hormone cycles. And grey-market botulinum toxin, the most potent toxin known, has put users in the hospital with botulism.

None of these belong in a source-it-and-inject-yourself workflow; several can be fatal on a single mistake. If you are weighing any of them, that is a conversation for a physician, not a vendor.